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Therapy Herbal Untuk Kanker

Sabtu, 15 Desember 2007

Hampir setiap orang pernah mendengar tentang beberapa jenis kanker. Daftar dari jenis kanker sangatlah panjang dan membingungkan. Yang hanya bisa disimpulkan dari keseluruhan jenis kanker yang ada saat ini adalah mereka semua dipicu oleh satu sebab yang umum, yaitu : sel-sel ganas. Sel-sel ganas ini disebut sebagai radikal bebas. Meskipun para pakar pengobatan saat ini telah mengetahui bahwa penyebab utama dari kanker adalah radikal bebas mereka masih mempergunakan lokasi pengobatan khusus untuk menghancurkan tumor. Metode ini hanya menghambat pertumbuhannya tanpa sekalipun menyentuh inti permasalahannya. Para ahli herbal telah melakukan penelitian untuk mengetahui apa yang menjadi penyebab dari radikal bebas tersebut. Sehingga akhirnya didapatkan suatu kesimpulan bahwa radikal bebas disebabkan oleh kekacauan daya tahan tubuh. Mekanisme sistem pertahanan tubuh menjadi rusak dan memproduksi sel-sel yang dapat menghancurkan dirinya sendiri dengan sasaran pada sel-sel yang baik dalam proses penghancuran integritas sel-sel tersebut.
AV Metacare telah dipersiapkan untuk menjadi sebuah inovasi baru yang ditujukan untuk melakukan pencegahan terhadap penyebaran sel-sel kanker atau metastasis dengan dua cara kerja dasar, yaitu : aktifitas Immunomodulatory dan aktifitas anti Metastatik. Komposisi herbal AV Metacare terdiri dari tumbuhan pilihan yang diperoleh dari penelitian selama bertahun-tahun. Tumbuhan ini, terbukti secara klinis, memiliki bahan yang mengandung immunomodulatory dan mampu mengawasi penyebaran sel kanker dengan cara mengikat pada permukaan luar protein E-Cadherin sehingga menghalangi adhesi sel kanker ke dalam jaringan yang masih baik. Proses ini mencegah penyebaran sel kanker dan memastikan bahwa perlindungan alami tubuh membiarkan berbagai perubahan biokimia dalam tubuh menjadi normal kembali. Kapasitas antioksidan dalam tumbuhan ini telah diakui oleh kalangan dunia pengobatan internasional dalam memainkan peranan yang penting untuk perlindungan terhadap kanker serta pengawasan penyebaran kanker dengan bertindak sebagai “free radical scavengers”
Hasil riset pada 50 penderita kanker payudara, AV Metacare terbukti menunjukkan kemajuan yang signifikan pada 41 penderita (82%) dengan hasil test menurun/melemahnya sel-sel kanker. Hal ini menunjukan bahwa AV Metacare merupakan anti oksidan yang sangat kuat.


Most people have heard of a few Cancers, the list of Cancers is long and perplexing. The one common thread that can be drawn from all Cancers is that they all seem to be caused by a common factor:- Rogue Cells. These Rogue cells, are called Free Radicals. Even though the modern Physician knows that the primary cause of cancers are free radicals, they still use site specific treatments to destroy tumors. The treatment is localized and does not address the core issue. Herbalism looks at the cause of free radicals. It is an established fact that Free Radicals are caused by an immune disorder. The body defense mechanism is impaired and produces self destructive cells that target good cells in the process destroying cellular integrity. Given below is a list of Cancers following which is an explanation of the herbs used to produce AV METACARE. Cancer is not one disease, but rather many related diseases. Cancer is typed according to the part of the body where it is located and the kind of cells that comprise it. The most common types of cancer cells and their locations are:
Carcinomas originate in skin tissue or tissues that line the body cavities and such internal organs as the lungs, breast, colon, and intestines.
Sarcomas grow in bones and connective tissues between organs and skin, and sometimes spread into the blood or lymphatic system.
Lymphomas are cancers of the lymphatic system, usually occurring in the lymph nodes.
Leukemias form in the blood or circulatory system, particularly in the bone marrow, which is the site of blood cell production.
Myelomas are tumors of bone marrow cells and frequently form simultaneously in many sites, including the ribs, vertebrae, and pelvic bones.
Composition
Withaniasomnifera: One of Ayurveda’s most powerful herbs, Withania somnifera has been the subject of over 100 international clinical studies. The role of the herb in various immune disorders, endocrine disorders, its anti-inflammatory activity, the anxiolytic activity of its extracts has been established beyond doubt. Yet, the most important activity of Withania remains its potent immunomodulating activity. A study Davis L, & Kuttan G, showed the effect of Withania somnifera on the cellular immune responses (CMI) was studied in normal as well as tumour bearing animals. Administration of Withania extract was found to enhance the proliferation of lymphocytes, bone marrow cells and thymocytes in responses to mitogens. Both PHA and Con A mitogens along with Withania treated splenocytes, bone marrow cells and thymocytes could stimulate proliferation twice greater than the normal. Withania treated splenocytes along with the mitogen LPS (10 microg/ml) could stimulate the lymphocyte proliferation six times more than the normal. Natural killer cell activity (NK) was found to be enhanced significantly in both the normal and the tumour bearing group and it was found to be earlier than the control (48.92% cell lysis). Antibody dependent cellular cytotoxicity (ADCC) was found to be enhanced in the Withania treated group on the 9th day (65% cell lysis). An early Antibody dependent complement mediated cytotoxicity (ACC) was observed in the Withania treated group on day 13 (47% cell lysis). J Prakash and co workers demonstrated the chemopreventive effect of Withania somnifera root extract (WSRE) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin cancer in Swiss albino mice. The skin lesions were induced by the twice-weekly topical application of DMBA (100 nmol/ 100 microliters acetone) for 8 wk on the shaved back of mice. WSRE was administered at the maximal tolerated dose of 400 mg/kg p.o. three times per week on alternate days 1 wk before DMBA and continued for 24 wk thereafter. The results of the study revealed a significant decrease in incidence and average number of skin lesions in mice compared with DMBA alone at the end of Week 24. Biochemical parameters were assessed in the lesions of WSRE-treated and untreated control mice. A significant impairment was noticed in the levels of reduced glutathione, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase in skin lesions of DMBA-treated control mice compared with vehicle-treated mice. These parameters were returned to near normal by administration of WSRE to DMBA-treated mice. The above findings were supported by histopathological studies. From the present study, it can be inferred that WRSE possesses potential chemopreventive activity in this experimental model of cancer. The chemopreventive activity may be linked to the antioxidant/free radical-scavenging constituents of the extract. The anti-inflammatory and immunomodulatory properties of WSRE are also likely to contribute to its chemopreventive action. In a study by Russo A, and co workers the free radical scavenging capacity of methanolic extracts from Witania Somnifera was investigated as well as and the effect on DNA cleavage induced by H2O2 UV-photholysis. In addition, the investigators investigated whether the plant extracts are capable of reducing the hydrogen peroxide-induced cytotoxicity and DNA damage in human non-immortalized fibroblasts. The extract showed a dose-dependent free radical scavenging capacity and a protective effect on DNA cleavage;. These results were confirmed by a significant protective effect on H2O2-induced cytoxicity and DNA damage in human non-immortalized fibroblasts. These antioxidant effects of active principle of Withania Somnifera may explain, at least in part, the reported anti-stress, immunomodulatory, cognition-facilitating, anti-inflammatory and antiaging effects produced by the plant extracts in experimental animal and in clinical situations and may justify the further investigation of its other beneficial biological properties. Tinospora cordifolia: A reputed immunoprotector, this herb is used in Ayurveda for longevity. Its role as an immunoprotector has been established in various clinical trials and the extract of this herb has demonstrated significant immunomodulating properties. Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700 microg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically generated superoxide anion at 500 microg/ml concentration and above with an IC50 value of 2000 microg/ml. Aqueous extract inhibited the formation of Fe2+-bipiridyl complex and formation of comet tail by chelating Fe2+ ions in a dose dependent manner with an IC50 value of 150 microg/ml for Fe2+-bipirydyl formation and maximally 200 microg/ml for comet tail formation, respectively. The extract inhibited ferrous sulphate mediated lipid peroxidation in a dose-dependent manner with an IC50 value of 1300 microg/ml and maximally (70%) at 2000 microg/ml. The results reveal that the direct and indirect antioxidant actions of T. cordifolia probably act in corroboration to manifest the overall radioprotective effects. Jagetia and co workers have shown that the exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of Tinospora cordifolia extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, methylene chloride extract enhanced the cell killing effect by 2.8- and 6.8-fold when compared either to methanol or aqueous extract at 50 and 100 microg/ml, respectively. Conversely, the frequency of micronuclei increased in a concentration-dependent manner in Tinospora cordifolia-treated groups and this increase in the frequency of micronuclei was significantly higher than the non-drug-treated control cultures and also with respect to 5 microg/ml Tinospora cordifolia extract-treated cultures, at the rest of the concentrations evaluated. Furthermore, the micronuclei formation was higher in the methylene chloride extract-treated group than in the other two groups. The dose response relationship for all three extracts evaluated was linear quadratic. The effect of Tinospora cordifolia extracts was comparable or better than doxorubicin treatment. The micronuclei induction was correlated with the surviving fraction of cells and the correlation between cell survival and micronuclei induction was found to be linear quadratic. Our results demonstrate that Tinospora cordifolia killed the cells very effectively in vitro and deserves attention as an antineoplastic agent Ocimum sanctum: Holy Basil as it is commonly known is considered a herb of the Gods. Its adaptogenic properties make this a particularly important plants in the prevention of immune disorders. Researchers at the Department of Horticulture and National Food Safety and Toxicology, Michigan State University, USA. have demonstrated the antioxidant activity of the herb extracts.Two Researchers, Vrinda B & Uma Devi P , have shown that Orientin (Ot) and Vicenin (Vc), two water-soluble flavonoids isolated from the leaves of Indian holy basil Ocimum sanctum have shown significant protection against radiation lethality and chromosomal aberrations in vivo. Other researchers at The Department of Horticulture and National Food Safety and Toxicology, Michigan State University, USA have demonstrated the anti-oxidant activity by bioassay-directed extraction of the fresh leaves and stems of Ocimum sanctum and purification of the extract yielded the following compounds; cirsilineol [1], cirsimaritin [2], isothymusin [3], isothymonin [4], apigenin [5], rosmarinic acid [6], and appreciable quantities of eugenol. The structures of compounds 1-6 were established using spectroscopic methods. Compounds 1 and 5 were isolated previously from O. sanctum whereas compounds 2 and 3 are here identified for the first time from O. sanctum. Eugenol, a major component of the volatile oil, and compounds 1, 3, 4, and 6 demonstrated good antioxidant activity at 10-microM concentrations. Anti-inflammatory activity or cyclooxygenase inhibitory activity of these compounds were observed. Eugenol demonstrated 97% cyclooxygenase-1 inhibitory activity when assayed at 1000-microM concentrations. Compounds 1, 2, and 4-6 displayed 37, 50, 37, 65, and 58% cyclooxygenase-1 inhibitory activity, respectively, when assayed at 1000-microM concentrations. Researchers studying the incidence of papillomas and squamous cell carcinomas have shown that these significantly reduced, and treatment with extracts of Ocimum sanctum increased the survival rate in the topically applied leaf paste and orally administered extracts to animals. Orally administered aqueous extract have showed profound effect in Histopathological observations made on the mucosa confirmed these findings. Further fluorescent spectral studies at 405 nm excitation on the mucosa of control, DMBA and extracts orally administered experimental animals showed a prominent maxima at 430 nm for control, 628 nm for DMBA induced carcinomas while aqueous and ethanolic extracts administered animals showed at 486 nm and 488 nm, respectively. The fluorescent intensity at 630 nm (FI630 nm) was significantly reduced and the ratio of fluorescent intensities at 520 nm and 630 nm (FI520 nm/630 nm) were significantly increased in orally administered extracts compared to DMBA treated animals. These observations suggest that the orally administered extract of O. sanctum may have the ability to prevent the early events of carcinogenesis. A study by Banerjee S and co workers, reports the modulatory influence of extract from the leaves of Ocimum sanctum on the activities of cytochrome p-450, cytochrome b5, and aryl hydrocarbon hydroxylase enzymes in the liver and glutathione-S-transferase and reduced glutathione level in the liver, lung, and stomach of the mouse. Oral treatment with the leaf extract at 400 and 800 mg/kg body wt for 15 days would significantly elevate the activities of cytochrome p-450 (p <>Citrus aurantium: Modified pectins extracted from this plant yield compounds that have anti-metastatic activity. Avraham Raz, PhD, director of the tumor progression and metastasis lab at Detroit's Barbara Ann Karamanos Cancer Institute, became interested in the way cancer cells clump together to form tumors. He found that this clumping needed sticky sugars -- and that pectins can keep these sugars from sticking. Normal pectins won't work in the blood stream. But Raz's team found a way to alter pectin so that it could be digested and enter the blood. And that's not all. In a recent issue of the Journal of the National Cancer Institute, Raz and colleagues showed that these modified citrus pectins cut the size of tumors in mice with implanted human breast and colon cancers. A team of researchers at Wayne State University, School of Medicine, and Department of Pathology, Karmanos Cancer Institute, Detroit, MI, USA. studied the effects of high pH- and temperature-modified citrus pectin (MCP), a nondigestible, water-soluble polysaccharide fiber derived from citrus fruit that specifically inhibits the carbohydrate-binding protein galectin-3, on tumor growth and metastasis in vivo and on galectin-3-mediated functions in vitro. METHODS: In vivo tumor growth, angiogenesis, and metastasis were studied in athymic mice that had been fed with MCP in their drinking water and then injected orthotopically with human breast carcinoma cells (MDA-MB-435) into the mammary fat pad region or with human colon carcinoma cells (LSLiM6) into the cecum. Galectin-3-mediated functions during tumor angiogenesis in vitro were studied by assessing the effect of MCP on capillary tube formation by human umbilical vein endothelial cells (HUVECs) in Matrigel. The effects of MCP on galectin-3-induced HUVEC chemotaxis and on HUVEC binding to MDA-MB-435 cells in vitro were studied using Boyden chamber and labeling assays, respectively. The data were analyzed by two-sided Student's t test or Fisher's protected least-significant-difference test.

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