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Usus besar dan usus tebal adalah merupakan bagian-bagian dari sistem pencernaan tubuh, dimana terjadi proses pemindahan zat makanan dari makanan yang kita makan dan menyimpan sisa pengolahan tersebut sampai semua dikeluarkan dari tubuh. Karena seringnya zat makanan bertumpuk pada bagian ini sehingga menimbulkan toksin yang dapat memicu terjadinya kanker. Kanker yang dimulai di usus besar disebut kanker usus besar. Kanker yang dimulai di usus tebal disebut sebagai kanker dibagian dubur (Colorectal Cancer). Penyebab pasti dari kanker colorectal tidak dapat diketahui secara tepat. Akan tetapi dari penelitian, secara umum kanker colorectal dapat disebabkan karena faktor-faktor : bertambahnya usia, diet, polip yang tumbuh pada usus besar, bisul colitis, sejarah kesehatan keluarga serta sejarah kesehatan pribadi. AV Colex adalah produk yang dikembangkan secara ilmiah untuk menangkal racun pada usus besar serta membantu mengurangi tekanan pada usus dalam proses pembuangan dan pengeluaran sisa bahan-bahan cernaan tanpa merusak bagian pelapis perlindungan. Dalam beberapa kasus kebiasaan diet yang tidak baik menyebabkan tubuh menjadi kekurangan serat dan dipicu pula oleh timbulnya stres, maka tubuh tidak dapat membuang sisa-sisa bahan cernaan secara sempurna, hal ini menyebabkan terjadinya keracunan di urat-urat usus. AV Colex mengandung bahan yang berguna untuk pembersihan halus. Bahan tersebut berfungsi membantu proses pembuangan secara alami oleh tubuh dengan jalan membuat beberapa racun dicampur dengan aman menjadi satu untuk mempermudah proses pengangkutan racun-racun tersebut. Dengan demikian, selain dapat menghilangkan tumpukan toksin di usus, juga akan meningkatkan kualitas pencernaan karena makin maksimalnya penyerapan nutrisi oleh dinding usus.

The colon and rectum are parts of the body's digestive system, which removes nutrients from food and stores waste until it passes out of the body. Together, the colon and rectum form a long, muscular tube called the large intestine (also called the large bowel). The colon is the first 6 feet of the large intestine, and the rectum is the last 8 to 10 inches.

Cancer that begins in the colon is called colon cancer, and cancer that begins in the rectum is called rectal cancer. Cancers affecting either of these organs may also be called colorectal cancer.

The exact causes of colorectal cancer are not known. However, studies show that the following risk increase a person's chances of developing colorectal cancer:Age: Colorectal cancer is more likely to occur as people get older. This disease is more common in people over the age of 50. However, colorectal cancer can occur at younger ages, even, in rare cases, in the teens. Diet: Colorectal cancer seems to be associated with diets that are high in fat and calories and low in fiber. Researchers are exploring how these and other dietary factors play a role in the development of colorectal cancer. Polyps: Polyps are benign growths on the inner wall of the colon and rectum. They are fairly common in people over age 50. Some types of polyps increase a person's risk of developing colorectal cancer. A rare, inherited condition, called familial polyposis causes hundreds of polyps to form in the colon and rectum. Unless this condition is treated, familial polyposis is almost certain to lead to colorectal cancer. Personal medical history: Research shows that women with a history of cancer of the ovary, uterus, or breast have a somewhat increased chance of developing colorectal cancer. Also, a person who has already had colorectal cancer may develop this disease a second time. Family medical history: First-degree relatives (parents, siblings, children) of a person who has had colorectal cancer are somewhat more likely to develop this type of cancer themselves, especially if the relative had the cancer at a young age. If many family members have had colorectal cancer, the chances increase even more. Ulcerative colitis: Ulcerative colitis is a condition in which the lining of the colon becomes inflamed. Having this condition increases a person's chance of developing colorectal cancer. Having one or more of these risk factors does not guarantee that a person will develop colorectal cancer. It just increases the chances. People may want to talk with a doctor about these risk factors. The doctor may be able to suggest ways to reduce the chance of developing colorectal cancer and can plan an appropriate schedule for checkups.

Composition
Aloe vera:
The miracle herb as it is known across the globe yields a variety of medicinally active compounds. Amongst the more important compounds from Aloe vera is a group known as anthraquinones of which Aloin forms a major part. Aloin is a proven purgative widely used in the field of medicine. Aloe contains at least three anti-inflammatory fatty acids that are helpful for the stomach, small intestine and colon. It naturally alkalizes digestive juices to prevent hyperacidity - a common cause of indigestion. It helps cleanse the digestive tract by exerting a soothing, balancing effect. In a study by Ishii Y et al, Aloe-emodin-9-anthrone(AE-anthrone), produced from barbaloin in the rat large intestine, caused not only an increase in the intestinal water content but also stimulated mucus secretion. This might play an important role in the occurrence of diarrhea. It was demonstrated that the amount of AE-anthrone produced in the rat large intestine(maximal amount: 568 micrograms/rat at 4 h after injection) was enough to cause both of these effects, which were observed following intracecal administration of barbaloin (31.1 mg/kg). These results together with our previous data, which showed a relationship between increase in the intestinal water content and the stimulation of peristalsis, confirm that AE-anthrone is the principal agent responsible for the cathartic effect of barbaloin. We also propose that the increase in water content is a more important factor than stimulation of peristalsis in the induction of diarrhea by barbaloin. Odes & Madar conducted a study to evaluate the effect of a novel laxative preparation, composed of Aloe vera and other herbal ingredients in patients with chronic constipation. Thirty-five men and women were randomized to receive capsules containing the Aloe vera formula, or placebo, in a double-blind trial lasting 28 days. Symptoms in the last 2 weeks of the treatment period were compared to those in the 14-day pre-trial basal period. In the Aloe vera group, bowel movements became more frequent, the stools were softer and laxative dependence was reduced. In the placebo group, all these parameters were unchanged. Abdominal pain was not reduced in either group. The results of this study show that the preparation is an effective laxative in the treatment of constipation.

Tribulus terrestris:
This herb is widely used in India for treating a variety of disease. Also found in Bulgaria it is used for impotency. One of the major medicinal uses is as a urinary cleanser. It is a diuretic and helps eliminate toxins from the system.

Trachyspermum ammi:
This herb is widely utilized as a spice in Indian cooking. It is used for its flavor and carminative activity. The fruit of the plant is antispasmodic as well and a digestive. The seed, and especially the essential oil in the seed, is strongly antiseptic, antispasmodic, aromatic, bitter, diaphoretic, digestive, diuretic, expectorant and tonic. It is used internally in the treatment of colds, coughs, influenza, asthma, diarrhoea, cholera, colic, indigestion, wind, oedema, arthritis and rheumatism. The seed is harvested when fully ripe and either distilled for the essential oil or dried for later use.
The seed contains about 4 - 6% essential oil, of which 45 - 55% is the strongly antiseptic essential oil 'thymol. The essential oil is also added to cough medicines. The root is carminative and diuretic

Cassia angustifolia:
The leaves of the plant yield the most popular purgative. Sennosides are the most medicinally active purgatives and used in Modern medicine across the globe. Two aloe-emodin dianthrone diglucosides (I and II) were isolated from the leaves of Cassia angustifolia Vahl by successive column chromatography with Amberlite XAD-2, silica gel, Polyamide C-200 and Sephadex LH-20. The stereostructures of I and II were elucidated as trans and meso isomers at 10-10', respectively, from the patterns of the ultraviolet absorption spectra and circular dichroism curves. This is the first report of isolation of diglucoside I from senna. Despite the lack of purgative activity, diglucoside I exerts a potentiating effect of about 1.3 times on the purgative activity of sennoside A in mice when even 15% is included in the mixture. The difference between I and a third active glycoside based on aloe-emodin is also discussed.

Triphala:
Triphala is a combination of three fruits Terminalia chebula, Terminalia belerica and Emblica officinalis. In combination the fruits produce a mild laxative activity which synergizes that of the other ingredients.

Ficus carica:
Commonly known a Fig, the fruit of the fig tree is used in India and the Middle East as a cure for constipation. Fig extract has proven to be a mild safe laxative. The fruit is mildly laxative, demulcent, digestive and pectoral. The unripe green fruits are cooked with other foods as a galactogogue and tonic. Syrup of figs, made from the fruit, is a well-known and effective gentle laxative that is also suitable for the young and very old